european nucleotides
and bone consortium

ATP is best known as the ‘currency’ of energy within living cells.

However, ATP and other nucleotides also act as important messenger molecules for cell-to-cell communication. The responses of cells to ATP are mediated via specific specific recognition sites, known as P2 receptors.

Recent research shows that ATP and P2 receptors play important and complex roles in the regulation of bone turnover, exerting powerful actions on both the bone forming cells (osteoblasts) and the bone destroying cell (osteoclasts).

There is increasing interest in the possibility that ATP and P2 receptors could also be involved in the pathogenesis of common bone disorders such as osteoporosis, which results from an imbalance in the actions of osteoclasts and osteoblasts.

The European Nucleotides and Bone Consortium exists to facilitate collaboration between the leading European research groups working on ATP, P2 receptors and bone. The consortium fosters cross-border, translational research, bringing together state-of-the-art work on the physiology and molecular biology of bone cells with molecular genetics and patient-based studies. To date, consortium members have published more than 1450 papers in peer-review journals, including more than 40 papers on ATP, P2 receptors and bone, as well as a recent monograph.

   


Information on collaborating centres can be found here.


This page last modified  January, 2009 by Alison Gartland
Copyright 2006-2009 european nucleotides and bone consortium

This project is supported through Coordination Theme 1 (Health) of the European Community's FP7, Grant agreement number HEALTH-F2 2007-202231.